the first example of a copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has been developed, leading to a wide range of 2-substituted quinazolines in moderate to excellent yields. the ef?ciency of this transformation was demonstrated by compatibility with a wide range of functional groups. thus, the method represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.
