祝贺徐清和李欢老师指导的研究生在the journal of organic chemistry上发表学术论文-威尼斯人888

abstact：a specific n-alkylation of 2-hydroxypyridines is achieved by reacting with organohalides under catalyst- and base-free conditions. the observed hx-facilitated conversion of pyridyl ether intermediates to 2-pyridone products may account for the success and specific n-alkylation of the reaction under the unexpectedly simple conditions. this new reaction may provide a useful alternative for the synthesis of 2-pyridones and analogous structures because of its >99% n-selectivity, relatively broad scopes of both substrates, and no mandatory use of catalysts and bases.

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